Tikhon was born in 1865 into an Orthodox Russian family. Ordained to the priesthood, he eventually became a bishop and was assigned as the Russian Orthodox Bishop of the Aleutians and North America from 1898 to 1907, during a crucial period of Orthodox missionary work in North America. During his tenure, Tikhon demonstrated remarkable openness to Episcopalian clergy and lay leaders, encouraging dialogue and cooperation between the Orthodox and Anglican communions. In 1917, following the Russian Revolution and the restoration of the patriarchate (which had been dormant since 1700), Tikhon was elected Patriarch of Moscow. In this capacity, he became the primary defender of Orthodox Christianity against Bolshevik ideology and Soviet state pressure. He was imprisoned multiple times, interrogated, and subjected to intense pressure to renounce his faith and his position. Despite these trials, he maintained his commitment to Orthodox Christianity and ecumenical witness. He died on April 7, 1925 (October 9 in the Orthodox calendar), under circumstances suggesting Soviet pressure and possible poisoning. The Russian Orthodox Church canonized him as a saint in 1989, recognizing his steadfast faith and martyrdom under persecution.

Tikhon is venerated in the Orthodox tradition as a confessor who endured persecution under communist atheism while maintaining fidelity to Orthodox Christianity and the patriarchate. His ecumenical outreach during his American episcopate is recognized as a significant moment in Orthodox-Anglican relations. He exemplifies Orthodox resistance to totalitarianism and the cost of faith under persecution. His canonization in 1989 marked the post-Soviet recognition of his holiness and martyrdom.